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Title: Biomedical and Histological changes in the Kidney of Streptozotocin-Induced Diabetic Rats. Effects of Garlic and Ginger Compared to Asprin
Authors: Mouna Jassim Alhouli 
Supervisor: Dr. Martha Thomson
Keywords: Diabetes, Garlic, Ginlkjnger, Asprin, Kidney, Nephropathy
Issue Date: 2010
Publisher:  Kuwait university - college of graduate studies
Abstract: This study was conducted to determine the biochemical and histological efficacies of garlic and ginger in comparison to aspirin in streptozotocin (STZ)- induced diabetic rats. One week after STZ injection, diabetic rats (blood glucose > 16.5 mmol/l) were divided into four groups three of which were treated for 8 weeks with daily doses of garlic extract, ginger extract (500 mg/kg body weight (BW) each) or aspirin (10 mg/kg BW). The fourth group served as diabetic control group. A normal (non-diabetic) control group was included for comparative purposes and received saline only. With regard to the physiological and clinical parameters, the results showed that compared to the diabetic control rats, treatment of STZ-induced diabetic rats with garlic or ginger caused more than 70% reduction in the blood glucose level, significant decreases in urine output and systolic blood pressure, and significant increases in body weight. However, only treatment with ginger produced significant reduction in food and water intake of STZ-induced diabetic rats. In contrast, treatment of STZ-induced diabetic rats with aspirin did not affect any of these parameters. As biochemical parameters, kidney malondialdehyde (MDA), lactate dehydrogenase (LDH), catalase (CAT), protein and total antioxidants were measured. The results showed that kidney MDA and LDH levels of diabetic control rats were significantly increased compared to the normal controls as well as the garlic-, ginger- and aspirin-treated animals. Total antioxidants levels of untreated diabetic rats were significantly lower than those of both the normal controls and the three treated groups. CAT activity and protein level of untreated diabetic rats were significantly decreased compared to the normal controls and the garlic- and ginger-treated groups. Aspirin-treated rats were not statistically different from the diabetic control rats in regard to CAT and protein and from the garlic- and ginger-treated rats with respect to MDA and total antioxidants. Histologically, diabetic renal corpuscles showed general distortion, in particular deterioration in capsular membrane and reduction in capsular space. All treatments attenuated the renal corpuscle modulation with more potency exerted by garlic and ginger. Results suggest that the hypoglycemic effects of garlic and ginger may help in ameliorating diabetic nephrology, and it is concluded that these two herbs may be administered as a supplementary precaution against diabetes.
Appears in Programs:0540 Medical Biochemistry (M.Sc.)

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