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Title: Study of Norovirus in Kuwait
Authors: Amirah Nasser Al-Rashidi 
Supervisor: Prof. Manuel John Albert
Keywords: Norovirus;norovirus-associated gastroenteritis;Kuwait;screening for norovirus infection;epidemiology of norovirus
Issue Date: 2012
Publisher:  Kuwait university - college of graduate studies
Abstract: Norovirus is considered to be the leading cause of acute gastroenteritis worldwide. The impact of this virus infection is not fully known in Kuwait. This study was aimed to determine the prevalence of norovirus-associated gastroenteritis in Kuwait and to identify the circulating genotypes. A total of 171 stool samples of patients with gastroenteritis were collected from different age groups, at 3 hospitals in Kuwait: Al-Adan, Al-Farwaniya, and Mubarak Al-Kabir hospitals, during 2005-2011. The stool samples were screened for norovirus using ELISA and reverse transcriptase polymerase chain reaction (RT-PCR). Norovirus was found to be the cause of 8.2 % (n=14) by RT-PCR. Norovirus infection was mostly detected in children under 5 years of age (86% [n=12]). Phylogenetic tree analysis has shown that 50% of the norovirus strains belonged to the genotype GII.4, and the predominant strain was GII.4 2006b. Other detected genotypes were GII.12, GII.b, GII.3, GII.8, and GII.7. This study highlights the importance of screening for norovirus infection in acute gastroenteritis and the importance of having a reporting system to identify sources of infection and to better understand the epidemiology of norovirus infection in Kuwait.
Appears in Programs:0520 Microbiology (M.Sc.)

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