Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/199
Title: Effect of Oral Administration of Garlic (Allium sativum) in Streptozotocin-Induced Diabetic Rats
Authors: سلمى علم الدين 
Supervisor: د. مارثا تومسون
Keywords: Garlic Allium sativum Streptozotocae Diabetes
Issue Date: 2015
Publisher:  Kuwait university - college of graduate studies
Abstract: iv ABSTRACT This study was conducted to determine the effects of oral garlic administration on streptozotocin-induced diabetic rats. One week after streptozotocin injection, diabetic rats (blood glucose > 16.5 mmol/l) were divided into two groups, one served as diabetic control and the other one received oral garlic extract (500 mg/kg) for 8 weeks. A normal nondiabetic group was included for comparative purpose and received saline only. With regard to physiological and clinical parameters, the results showed that garlic treatment of streptozotocin-induced diabetic rats, significantly, reduced blood glucose level (about 50%) compared to diabetic control rats, decreased urine output, food intake and water intake and increased body weight and serum insulin. For lipid profile, diabetes caused a significant increase in both serum cholesterol and triglycerides. Garlic treatment significantly reduced both parameters. For biochemical parameters, malondialdehyde, lactate dehydrogenase, catalase, alkaline phosphatase, protein and total antioxidants were measured in different tissues. Results showed that kidney and liver malondialdehyde levels were significantly increased in diabetic control rats compared to both normal control rats and garlic treated diabetic rats. Total antioxidants in serum, liver and kidneys were significantly lower in diabetic control rats compared to normal control rats as well as garlic treated diabetic rats. Catalase and total protein were significantly decreased in diabetic control rats compared to normal control and garlic treated diabetic rats. Alkaline phosphatase and lactate dehydrogenase were significantly increased in diabetic control rats compared to normal control rats as well as garlic treated diabetic rats. Urine analysis showed significant increase in protein, glucose and creatinine in diabetic control rats compared to both normal control and garlic treated rats. Oral garlic feeding was found to be able to decrease diabetes symptoms as well as oxidative stress. These results suggest that oral garlic treatment may be helpful in lessening diabetic complications such as nephropathy and dyslipidemia. Thereby, garlic may be given orally as a supplementary precaution against diabetes.
URI: http://hdl.handle.net/123456789/199
Appears in Programs:0496 Biochemistry

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