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Title: Investigating Factors Involved in Post Laparoscopic Sleeve
Authors: المها محمد خالد الصباح 
Supervisor: د. وليد رينو
Keywords: Post Laparoscopic Sleeve Gastrectomy (LSG) Neuropathy
Issue Date: 2015
Publisher:  Kuwait university - college of graduate studies
Abstract: Laparoscopic Sleeve Gastrectomy (LSG) has gained popularity as the leading bariatric procedure for the treatment of morbid obesity. A serious complication of LSG is neuropathy. Unfortunately, little is known in terms of its risk factors. Due to an increase in obesity and rising numbers of bariatric surgeries, neurologic complications have become increasingly recognized. Our aim was to examine the biochemical, hormonal, and genetic factors that are associated with neuropathy in patients post LSG. 32 patients were included in the study; 16 patients with neuropathy in the neuropathic group (NG), 16 patients without neuropathy in the control group (CG). Diagnosis was made by a consultant neurologist and blood samples were taken to examine vitamin deficiencies, genetic analysis, and hormones involved in neuropathy (GLP-1). DNA extraction and genotyping was performed to investigate rs6234 SNP in the PCSK1 gene. Results showed the mean age of NG 34.9 while the CG was 26.6. There was no significant difference between BMI (p = 0.1) as well as excess weight loss percentages post LSG at 12 months (p = 0.6). B12 levels were within normal range, but higher in NG (p = 0.005). Vitamin B1 and B2 levels were significantly lower in NG; p values are 0.000 and 0.031, respectively. Vitamin B6 levels were significantly higher in NG (p = 0.02) Copper levels were lower in NG (p = 0.009). There was no significant difference in GLP-1 response. The allele frequency showed 81.8% of G-allele and 18.2% of C-allele while the genotypic frequency for GG, GC, and CC is 66.94%, 29.75%, and 3.31%, respectively. No significance between the three genotypes and GLP-1; only at minute 15 of time point (p = 0.03). In conclusion, our data showed post LSG neuropathy is associated with lower levels of vitamin B1, B2, copper, and are older in age. Vitamin B6 was significantly higher in the NG, which is, at toxic levels, associated with neuropathy. No difference in preoperative BMI, excess weight loss % at 1 year, and GLP-1 levels, rs6234 SNP were found. Larger data is required to validate our results.
Appears in Programs:0560 Anatomy

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