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Title: Haptoglobin in Relation to Myeloperoxidase and Prothrombotic Factors in Patients with Thromboembolism
Authors: Heba Samir Hasan Asaad 
Supervisor: Dr. Olusegun A. Mojiminiyi
Keywords: Haptoglobin Myeloperoxidase Thromboembolism
Issue Date: 2012
Publisher:  Kuwait university - college of graduate studies
Abstract: Haptoglobin is an acute phase protein that plays a key role in preventing the oxidative damage of tissues. It can bind to free heme containing ferric iron to inhibit the accumulation of harmful reactive oxygen species. It has been suggested that haptoglobin polymorphisms contribute to the incidence of thromboembolic diseases, however mechanisms of association are not fully understood. In addition, prothrombotic coagulation factors have a key role in the development of thromboembolic diseases. Many studies had shown that Hp2-2 gene polymorphism represents a risk factor for thromboembolic diseases. Myeloperoxidase is associated with acute myocardial infarction and may be used to predict mortality. The main hypothesis in this project is that there is a relation between haptoglobin, myeloperoxidase and prothrombotic factors in patients with thromboembolic diseases. Seventy two patients with cerebrovascular accident, age range 20-60 years, and seventy five healthy controls, age range 30-57, are included in this study. Basic hematological and biochemical parameters were estimated. Protein C (PC), protein S (PS), antithrombin (AT), and activated protein C resistance (APCR) functional assays were performed. Lupus anticoagulant (LA) test was also done. Measuring haptoglobin and myeloperoxidase level was done by doing ELISA. DNA extraction was done in order to do haptoglobin genotyping. Unfortunately, we faced many methodological problems in determining haptoglobin genotypes and, due to limitation of time, the genotyping could not be done.
Appears in Programs:0570 Pathology (M.Sc.)

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