Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/254
Title: The Effect of Systemic Hypertension on Myocardial Perfusion and Cardiac Diastolic & Systolic Function
Authors: Shaima K. Alfarsi 
Supervisor: Dr. Issa Loutfi
Keywords: Hypertension Myocardial Perfusion Cardiac Diastolic
Issue Date: 2015
Publisher:  Kuwait university - college of graduate studies
Abstract: Systemic hypertension is a common disease with associated complications in the heart including ischemia and heart failure. Abnormalities of perfusion and function (both systolic and diastolic) are amenable to study using Tc-99m lipophilic chelate gated-SPECT myocardial perfusion imaging (G-SPECT MPI). The objective is to use G-SPECT MPI in patients with hypertension for studying abnormalities of cardiac perfusion and function both systolic and, in particular, diastolic, to define findings that could be associated with hypertensive heart disease. Archived G-SPECT MPI studies for 48 hypertensive patients were retrieved and reprocessed. Findings related to perfusion (defects) and function: systolic (left ventricular ejection fraction (LVEF) and wall motion (WM)) and diastolic (peak filling rate (PFR) and time to peak filling (TTPF)) were recorded and cross-tabulated. The results showed 50% abnormal perfusion studies. Functional abnormalities were: WM 35%, LVEF 5%, PFR 33%, TTPF 44%. Combined functional systolic (WM or LVEF) and especially diastolic parameters (PFR or TTPF) provided the best definition of abnormalities that could be attributable to hypertensive heart disease. In conclusion, G-SPECT MPI provided evaluation of myocardial perfusion and cardiac systolic and diastolic function to define abnormalities of hypertensive heart disease which could be managed appropriately to avoid the serious consequences of coronary artery disease and heart failure.
URI: http://hdl.handle.net/123456789/254
Appears in Programs:0555 Nuclear Medicine (M.Sc.)

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