Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/337
Title: The Utility of Ki67, CK20, Mutant p53 and Cytochrome C Oxidase subunit 2 in Urothelial Carcinoma in Kuwait
Authors: Jumana Abbas Al-Ramzi 
Supervisor: Dr. Anwar Al-Banaw
Keywords: Ki67;Mutant p53;Cytochrome C
Issue Date: 2016
Publisher:  Kuwait university - college of graduate studies
Abstract: Pathological stage and grade are important parameters for determining the diagnosis and prognosis of urothelial carcinomas. However, this method for interpretation of tumours deemed insufficient due to the heterogeneous nature of urothelial carcinomas. Therefore, the utilisation of some immunohistochemical markers have been used to improve the criteria. Although some studies have demonstrated an association with certain markers, others using similar markers have been less convincing. In Kuwait, the diagnosis of urothelial carcinoma still depends on the interpretation of hematoxylin and eosin staining. Thus, including reliable immunohistochemical markers will help confirm the diagnosis and aid in the prognosis of the disease. We aimed to correlate the immunohistochemical expression of CCO2, CK20, Ki67 and mutant p53 in relation to grade and stage of urothelial carcinoma in a randomly selected Kuwaiti population sample. A total of 60 paraffin wax embedded samples (TURBT samples) were collected from 60 patients, consisted of stages; Ta, T1 and T2, were immunostained by using Ki67, CK20, mtp53 and CCO2 antibodies. According to the statistical analysis, there was a significant association with Ki67 positive expression with grade and stage. In addition, a statistical significant association of CK20 diffused expression was observed with grade and stage. A statistical significant association was also observed with positive expression of mtp53 with grade, but no association was found with stage. There was no statistical association of CCO2 expression with grade or stage. Overexpression of Ki67 and aberrant expression of CK20 prove to be useful immunohistochemical tools for predicting prognosis of the disease. Overexpression of mtp53 demonstrated its significance in grading but still remains controversial. CCO2 demonstrated no association with both parameters.
URI: http://hdl.handle.net/123456789/337
Appears in Programs:1100 Pharmaceutical Sciences

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