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Title: Effect of Resistant Starch (HAMS-260) on Calories Consumption, Body Composition, Minerals Metabolism, Blood Glucose level, Ghrelin, and Inflammation Markers in Growing Rats
Authors: Noura Abdullah Alrashidee 
Supervisor: Dr. Tasleem A. Zafar
Keywords: calories : inflammation
Issue Date: 2017
Publisher:  Kuwait university - college of graduate studies
Abstract: Obesity and diabetes have reached alarming levels worldwide with exceptional severity in Kuwait. The addition of resistant starch (RS) to foods is an attempt to lower both the energy density and glycemic index which can lead to weight loss and improve the metabolic profile. This study aimed to determine the effect of replacing 10% of the regular cornstarch with RS from high amylose maize starch (HAMS-260) in the feed of young rats on standard and high-fat high-sugar diet on body composition, inflammation status, mineral absorption and bone composition. Weanling rats were divided into 4 groups (n = 12/group) and fed the following diets for four weeks. Group 1 control (C) received AIN-93G growth diet; Group 2 (C+RS), received control + 10% RS; Group 3, received high-fat high-sugar (HFHS) diet; and Group 4 (HFHS+RS), received HFHS diet + 10% RS. The total food intake and weight gain were recorded. Right femur, abdominal fat, total gut, cecum, and cecum content were extracted and weighed. Mineral (Ca, Mg, and K) content in food, feces, and femur were analyzed by Inductively Coupled Plasma. Data were analyzed by SPSS. RS was effective in reducing food intake, total calories intake, body weight, and abdominal fat when fed to group 4 rats compared to group 3. However, RS increased food consumption by group 2 compared to C. The caloric intake and thus body weight, weight gain, and abdominal fat were not different between the two groups. Although body weight, disemboweled gut weight and corrected body weight of group 2 and group 3 were not different, there was a significantly lower abdominal fat deposition in group 2. RS significantly increased cecal weight, and feces production, and decreased cecal content pH in group 2 and 4 compared. There was no significant effect of RS on plasma glucose, serum IL-6, TNF-α, or serum ghrelin level and femur weight. The fecal Ca, Mg and K excretion was significantly higher in group 2 compared to C. Group 3 had the highest Ca excretion among all the groups. Group 4, fed HFHS+RS, showed a significant decline in the excretion of the three minerals compared to the rats on HFHS diet or C+RS diet. Reduced Ca excretion in feces by rats on HFHS+RS diet was reflected by an increased Ca absorption of 77% compared to 30% in group 3 on HFHS diet. Thus, adding RS to diets reduced caloric intake and abdominal fat mass, and enhanced mineral absorption in the growing rats.
Appears in Programs:1820 Nutrition Science & Food Science

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