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|Title:||Structural and Biological Studies on Thiosemicarbazones and Their Metal Complexes||Authors:||Manal Marzouq Abdullah Al-Shammari||Supervisor:||Dr. Othman A.Al- Fulaij||Keywords:||Biological : Thiosemicarbazones||Issue Date:||2018||Publisher:||Kuwait university - college of graduate studies||Abstract:||In this thesis, two ligands and their complexes with some transition metal cations were characterized. The ligands were HL1, 4-(2,4,6-trichlorophenyl)-3- thiosemicarbazide, and H2L2, (2E,2’E)-2,2’-(pyridine-2,6-diylbis(ethan-1-yl-1- ylidene))bis(N-(2,4,6-trichlorophenyl) hydrazinecarbothioamide). The ligand H2L2, was prepared by refluxing HL1 with 2-acetylpyridine. The two thiosemicarbazone ligands, HL1, and H2L2, may exist in two forms, thiol or thione, due to the existence of the thioamide group. Complexes of HL1 with V(IV), Co(II), Ni(II), Cu(II), Pd(II), and Pt(II) ; and of H2L2 with V(IV), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Pd(II), and Pt(II) were successfully synthesized in a pure state. The ligands and their complexes were characterized by elemental analysis, FTIR and mass spectrometry, nuclear magnetic resonance measurements (NMR), UV-visible spectroscopy, and X-ray diffraction spectroscopy, in addition to molar conductance and magnetic susceptibility studies and thermogravimetricanalysis. The results showed that the complexes of HL1 have the following chemical formulae and structures: [(VO)2(L1)(SO4)(C2H5O).H2O] (square based pyramidal structure), [Co2(HL1)Cl3C2H5OH]Cl (square planar structure), [Ni(HL1)Cl2]. 3H2O (trigonal planar structure), [Cu(L1)2(H2O)2] (octahedralstructure), [Pd(HL1)Cl2].H2O (weakly distorted square planar structure),and[Pt(HL1)Cl2]. ½ H2O (square planar structure).In case of H2L2, the complexes were found to have the following chemical formulae and structures: [VO(H2L2)SO4] (octahedral structure), [Mn(H2L2) C2H5OH)Cl].Cl (pentagonal bipyramidal structure), [Co2(H2L2)Cl2]2H2O.Cl2 (tetrahydralstructure), [Ni2(H2L2)Cl2]2H2O.C2H5OH.Cl2 (tetrhydral structure), [Cu2(L2)Cl2]H2O (square planar structure), [ZnL2] (square pyramidal structure), [Pd3(L2)Cl4] (square planar structure), and [Pt4(L2)Cl6] (square planar structure). All the complexes, except those of Pd(II) and Pt(II), were stable against temperatures up to more than 200oC where the first decomposition step starts. The Pd(II) and Pt(II) complexes with HL1 and H2L2 were more stable than the other complexes. The [Pt4 (L2) Cl6] v complex, was so thermally stable that it could not be decomposed within the temperature range of the instrument (up to 800oC). The ligands and all their complexes have been screened for their biological activity. The complexes had variable activity and some of them were found more reactive than the corresponding parent ligand.||URI:||http://hdl.handle.net/123456789/724|
|Appears in Programs:||0420 Chemistry (M.Sc.)|
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checked on Sep 26, 2020
checked on Sep 26, 2020
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